Significance

Stain

Breast carcinoma

ER , PR & Her-2

T or NK cell neoplasms vs other neoplasms

CD 3

Hodgkin's lymphoma vs thymoma

Hodgkin's lymphoma vs T-cell rich - B-cell lymphoma

CD 15

Gastrointestinal lymphoma vs carcinoma

B cell lymphoma vs T cell lymphoma

Large B cell lymphoma vs melanoma

CD 20

Lymphoma vs seminoma

Lymphoma vs carcinoma

Lymphoma vs sarcoma

Lymphoma vs melanoma

Leucocyte Common Antigen

(LCA – CD 45)

Carcinoma vs sarcoma

Carcinoma vs melanoma

Carcinoma vs lymphoma

Cytokeratin (CK)

Endometrioid carcinoma vs endocervical carcinoma

Vimentin

Pheochromocytoma vs adrenocortical tumour

Carcinoids vs carcinoma

Thyroid medullary carcinoma vs thyroid follicular carcinoma

Islet cell tumour vs acinic cell carcinoma

Chromogranin A

Sarcoma vs lymphoma

Sarcoma vs carcinoma vs malignant mesothelioma

Sarcoma vs melanoma

Desmin

Yolk sac tumour vs clear cell carcinoma

Embryonal carcinoma vs testicular seminoma

Alpha Fetoprotein

Mesothelioma vs carcinoma

Adenomatoid tumour vs hemangioma

Sex cord stromal tumour vs ovarian epithelial tumour

Calretinin

Colorectal carcinoma vs ovarian carcinoma

Colorectal carcinoma vs prostatic carcinoma

Thyroid medullary carcinoma vs thyroid follicular carcinoma

Urothelial carcinoma vs renal cell carcinoma

Pancreatic ductal carcinoma vs acinic cell carcinoma

Carcinoembryonic Antigen

(CEA or CD 66)

Leukemia vs lymphoma

Myeloperoxidase

Melanoma vs lymphoma

Melanoma vs leiomyosarcoma

Spindle cell melanoma vs spindle cell carcinoma

S – 100

Leiomyosarcoma vs giant gastrointestinal stromal tumour

Breast DCIS vs breast microinvasive carcinoma or adenocarcinoma

Smooth Muscle Actin