December 13, 2017
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Home >> Newsletter >> Hemoglobin Electrophoresis عربي

Hb Electrophoresis

 

Hemoglobin electrophoresis is the most practical method of diagnosing hemoglobinopathies. Hemoglobins are genetically controlled and presence of abnormal hemoglobins is often associated with functional, physical and morphological abnormalities in the erythrocytes as well as pathological manifestations, such as hemolytic anaemia.

 

NORMALS

 

Normals show an HbA1 band and a faint HbA2 band.

 

Normal Values are        HbA1       96-98.5%

                                       HbA2       1.5-4%

 

SICKLE TRAIT

 

This is a heterozygous state showing HbA1 and HbS with a normal amount of HbA2. The HbS concentration may vary from 20-50%.

 

SICKLE DISEASE

 

This is a homozygous state showing almost exclusively HbS. A small amount of HbF (<15%) may also be present.

 

THALASSAEMIA MINOR

 

This state shows HbA1 and HbA2. The HbA2 band is elevated to twice normal levels with a concentration of 5-8% in approximately 60% of the cases. HbA2 values between 4-5% probably represent thalassaemia minor, but repeated red cell morphological abnormalities must be present for confirmation.

 

SICKLE C DISEASE

 

This is a heterozygous state showing HbS (45-55 %) and HbC (45-55 %).

 

THALASSAEMIA-SICKLE DISEASE

 

This condition shows HbA1 (0-25 %), HbS (50-90 %), HbA2 (3-8 %) and HbF (2-20 %(.

           

THALASSAEMIA C DISEASE

 

This condition shows HbA1 (0-25%), HbF (2-20%) and HbC (60-90%). HbA2 cannot be measured.

 

C DISEASE

 

This is a homozygous state showing almost exclusively HbC and up to 5 % HbF.

 

THALASSAEMIA MAJOR

 

This condition shows HbF (70-90%), HbA1 (2-20%) and HbA2 (2-8%(.

 

CONDITIONS ASSOCIATED WITH ELEVATED FETAL HEMOGLOBIN (HbF) LEVELS

 

             Anaemias

             Myelofibrosis

             Postirradiation fibrosis of marrow

             Malignancies involving marrow

             Hemoglobinopathies

             Hereditary persistence of fetal hemoglobin

             Chromosomal abnormalities

             HbF syndrome with low HbA2 and carbonic anhydrase deficiency

             Bronchial asthma

             Familial HbF elevation

 


 
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