December 13, 2017
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Home >> Newsletter >> Helicobacter pylori Antigen عربي

Helicobacter pylori Antigen (Hp Ag)

 

 

Helicobacter pylori is a Gram negative bacterium, firstly isolated in gastric mucosa by Marshall and Warren in 1983. This bacterium is widely diffused in men, without limitations of sex and age; it has been found that infections can be transmitted directly by contact with contaminated biological fluids (Saliva, stool, body secretions) and also from contaminated food and beverages.

 

H. pylori, and in particular some pathogenic strains (Cag A+), is the etiological agent responsible of most of active infections and lesions of the gastric mucosa in man.

 

H. pylori infection moreover acts as cofactor in the development of tumor pathologies of the gastric apparatus and it is suspected to be associated to some inflammatory pathologies of the genital female apparatus, evolving toward neoplastic transformation.

 

At the present time, the identification of Helicobacter pylori is mostly made with either invasive histochemical technique (with the determination of its urease activity on an isotopic substrate with time consuming bacteriological culture systems) or with expensive molecular biology techniques (PCR).

 

ELISA for Hp Ag have been only recently introduced as a specific, fast, non invasive (analysis of stools) and cheaper method of detection.

 

Method of detection

Enzyme lmmunoassay (ELISA) for the one-step, qualitative/quantitative determination, of Helicobacter pylori Antigen (Hp Ag) in human stools. The kit may be used for the follow-up of Hp infected patients and their pharmacological treatment.

 

Sample Required

Stools from patients are used as a source of sample for the determination of Helicobacter pylori antigen.

 


 
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